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10 Best enzyme drain cleaners of 2021

Most lists of Best enzyme drain cleaners are too long. They focus on listing every enzyme drain cleaner under the sun instead of those that are actually worth buying. Even worse, because nobody knows drain cleaners in detail, such lists contain a lot of myths and assumptions.
So today, we’re going to take a unique approach. Rather than listing 50+ enzyme drain cleaners, we’ll talk about the ten that we think most deserve your attention.

Following is our list:

Let’s Pick the Best Enzyme Drain Cleaner (Detailed Review)

Drano Max Gel Drain Clog Remover and Cleaner

This product works best for garbage disposals, bathroom, kitchen and other drains. This is perfect in removing clogs. The formula of this enzymatic drain cleaner is specially for removing clogs removing clogs, cleaning showers or sink drains and blockages etc.

Drano Max Gel Drain Clog Remover is specially formulated to remove clogs in all showers, bathtubs, and sinks.
The product is safe to use on metal pipes, PVC, garbage disposals and septic systems. The product is made up of Water, Bleach, Cleaning agent, Corrosion Inhibitor, Caustic and a special formula.

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A funny review caught my attention. The reviewer is living in the house of long-haired women. Their drain used to clog constantly. They bought the brought, followed the instruction and they have clear sink and tub now.

Pros and Cons:

  • Formulated in a way to dissolve though clog.
  • Safe and natural product.
  • Fast and effective.
  • Works on bathtubs, shower and sinks etc.
  • The product breaks off inside the drain. (According to some users)
  • The product didn’t work (for some users) while removing clogs even minor ones.

The product works on toilets. But most clogs in toilets are caused by a lot of wastes. So, use a plunger (first) if you’re dealing with clogs cause by a lot of wastes (volume wise).

Similarly, the product also works on bath pipes. Drano Max Gel can be used on cast iron pipes.
According to a user, the product won’t help you if you want to remove a clog caused by cotton/terry cloth baby wash cloth.

Max-Gel also works on a backed-up basement floor drain. Similarly, the product is safe to use on bathroom and kitchen sinks where there is a garbage disposal.


DrainScrub Powder Enzyme Drain cleaner is environment friendly. The product has the capacity to remove clogs and end the “odor”. The microbes will not harm pipes.The product is packed with micronutrients. This increase the performance and makes it one of its kind products available out there.

DrainScrub Powder works best for septic tanks, showers, sinks, toilets and tubs etc. The product comes with easy to follow instructions for all kind of applications. It is one of the best enzymatic drain cleaner of 2020.

Drain Scrub is value for money. It’s a bit expensive but not much cheaper than calling a plumber every month.

Pros and Cons:

  • Best solution to blast away clogs and odors
  • Safe and environment friendly
  • The product has double strength as it includes double bacteria and enzymes as compared to its competitors.
  • The product didn’t work for some users.
  • Some users called it “not worth the money” as it is expensive.

As mentioned earlier, the product is safe to use on all pipes. With that being said, you can use it on old galvanized pipes.
An important point to note here is “this drainage cleaner must be applied to drain within 30 minutes after mixing. As DrainScrub has beneficial bacteria in it, these bacteria would die if you do not expose them to organic waste in the drain.

Keep in mind that this product is not specifically developed for washing machines and dishwashers. If you want a cleaner for those purposes, use BioFresh.

Bio Fresh is specifically formulated for washing machines and dishwashers.


If I had to say one sentence about this product, it would be “best product in term of budget”. Do not confuse it with cheap products. Bio-clean is efficient as well as effective when it comes to cleaning. The product contains a special combination of natural bacteria and enzymes. This combination an absolute beast at digesting dead organic waste.

At times, our plumbing system get filled with loads of dead organic waste such as grease, hair, soap scum, food particles and cotton etc. Such waste needs to be removed. You can’t $100-$500 on plumbers every other month. That’s where enzyme drain cleaners like Bio-clean comes to rescue our septic tanks.

I called it a “best budget product” because it can be used for up-to 100 drain treatments.

Bio-clean is environment friendly, so you won’t run into an issue while using it. The product is absolutely safe to use. (You need to keep it away from children- obviously)

Bio-Clean can be used to clean Kitchen sinks, septic tanks, motor homes, cat litter pans, showers, garbage disposals and bathtubs etc.

  • Capacity up-to 100 Drain Treatments
  • Multipurpose
  • Safe and natural
  • An Effective organic decomposer
  • The product wasn’t effective at removing the clogs.


Green Gobbler has a great drain cleaner, effective in dissolving soap, grease, hair and paper etc.
Being one of the best enzyme drain cleaner, Green gobbler has a highly effective formula that is capable to remove clogs of any sorts. The product has an ultra-thick formula that clings to pipes to keep them free and working.

The products works fast (sometimes within minutes). The product is different from drain openers. It’s fast, safe and effective.

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This drain cleaner is easy and safe to use. The formula is safe to use in pipes, toilets, sinks, showers and tubs. The formula is non-caustic.

Green Gobbler is unique as compared to other drain cleaners as it comes in a bottle with dual chambers. Dual chambers will help you avoid measuring creating a mess. You just need to pour one chamber at a time and the formula will start dissolving organic wastes. (Use one chamber tubs and sinks and two chambers for toilets).

This make it easy to keep the drain clean!

Pros and Cons:

  • Effective Formula
  • Fast
  • Safe and Natural
  • Comes with a Dual Chamber
  • The product wasn’t effective for some users. (Mostly reported on slow toilets).
  • Some users reported that the product isn’t fast.


Next in our list is another product by Green Gobbler. What is different in this product as compared to the above one? Well, this one is specially formulated to dissolve fats, cellulose, oils, greases, proteins, starches and other organic food wastes such as grease, hair, soap scum, food particles and cotton etc.

We have selected this enzyme drain cleaner as “our choice”. Why is that? We have a detailed review for that. Just keep reading with me.

The product is rapid. The company believes that the product is more effective than caustic chemicals. They are also allowing 30-Days money back Guarantee.

The formula has enzymes and bacteria in it. This combination helps in the increase of the efficacy of grease traps by allowing bacteria to work more effectively.

The enzymes in the formula help in dissolving organic wastes (such as grease, hair, soap scum, food particles and cotton etc.) inside pipes and tanks etc.
The product is safe to use in pipes, drain lines and septic tanks etc.

Pros and Cons:

  • Powerful and Effective than caustic chemicals
  • Rapid
  • Smells Fresh and clears odors
  • Safe to use on galvanized pipes
  • The product didn’t work for some users.
  • The product was ineffective on Grease Trap Smell for some users.


This one has been labelled as a commercial Enzyme drain cleaner. It’s more of a grease trap cleaner. The product has the capacity to clean slow draining sinks. This will help the drain be free and keep flowing. The product uses bacteria that produces enzymes to clean your drains. The enzyme cleans the drains by converting wastes into Carbon dioxide and water.

It is advised to use this product regularly. This practice will help the microorganisms to build colonies inside the trap. These colonies will reduce/prevent accumulation of FOG. This is very necessary as accumulated FOG can cause blockage in your line.

The product contains 100% Biodegradable enzymes, water and fragrance.

Pros and Cons:

  • Fast
  • Safe to use
  • Clear offensive odors
  • Helps in keeping grease traps and drain flowing
  • A user found it useless for restaurants. (However, the product worked well for another restaurant owner)
  • The product wasn’t effective for some users.

Does this product eliminate drain flies and their larvae?

There are mixed answers to this question. Let me tell you the fact and that is it does not directly eliminate drain flies and their larvae. But there are several indirect solutions to this problem. For example, you can use it to remove the food source of drain flies. An alternate solution is to use its smell. It would help in knocking drain flies out.

One thing to keep in mind is this product will not be effective on paper types of clogs. So, if you’re dealing with lots of paper wastes, use alternate products as suggested by us in this top 10 list.


The manufacturer (Roebic) is in business for about 50 years. They have got a hell of experience and are well equipped with the right tools to manufacture products that works. The product is specially formulated for dead organic wastes in sewer lines and main line of the house. K-97 has the capability to degrade the organic waste.

K-97 is effective and efficient. It has bacteria that can dissolve organic wastes i.e. fats, sludge, grease and paper etc.

K-97 is safe and easy to use. The product can be used on all pipes. K-97 works naturally while dissolving waste and restoring a proper flow.

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Pros and Cons:

  • Quick and Effective
  • Safe and environment friendly
  • Can digest fats, paper and Grease
  • Price is a bit high
  • Product wasn’t 100% effective for some users.


Flo-Zyme is another commercial enzyme based cleaner best for drain pipes and one of the best drain cleaners. The product has a specialty to open up tough clogged drains.
The formula is best for dissolving suspended solids like greases, oils, fats etc. One of the great features is its “pleasant scent”. The product works beautifully in dissolving wastes and eliminating foul odors. If you’re in need of a commercial enzyme drain cleaner, this is the product for you.

The formula contains 250 billion active enzymes. These enzymes are produced by specially developed bacteria. Dead organic wastes are first broken down. The resulting product is then liquified to dissolve it completely.

Flo-Zymes is non-pathogenic (products that do not cause harm, disease or death to an organism). The product is safe for animals, plants and marine life.

Pros and Cons:

  • Commercial enzyme drain cleaner
  • Pleasant Scent
  • Eliminates Foul odor
  • Contains 250 billion active ezymes
  • Safe to use
  • The product isn’t eco-friendly reported by some users.
  • The product didn’t work for slow drain for some users.


BioFresh Enzyme Drain Cleaner works best to eliminate odors such as garbage disposal odors, washing machine odors and dishwasher odors etc. The product is made in USA and is safe to use. BioFresh is environment friendly. The product works in a natural way to destroy wastes and odors.

Bio-Fresh is a concentrated product, 2 oz per treatment is recommended for most cases. The detailed instruction is given along with the product.

A thing to remember here is that BioFresh works only on clogs created by organic wastes. Such clogs are mostly created by rotten food, fats and oil etc.

Pros and Cons:

  • Works effectively in the natural way
  • Safe and environment friendly
  • Eliminate foul odor naturally
  • The product works but needs some patience (reported by some customers)
  • BioFresh didn’t work for slow bathtub drain (reported by a user)

Common Question: Will this product work on Slow Drain?
The answer is “it depends”. Yes, it depends on the cause of the slow drain. If the drain is because of organic wastes, then it would be wise to use this product. It’ll help. But if the case is otherwise like hairs, you should use a drain opener that has sulphuric acid in it.


A great product to dissolve grease, hair buildup and protein in a natural way. The product is made up-of enzyme powder.
Earth Enzymes Drain Opener is safe for animals and plants. The product is non-corrosive. So it’s safe to use on pipes.
The manufacturer has about 50 years of experience in producing cleaning products. The company is committed to help you make your home a healthy one.

The product is might not be effective if your goal is to get rid of drain flies. In that case, baking soda combined with vinegar might work like a magic for you.

According to a user, the product will work on standing water. While another user was of a different opinion.
The product is safe to use on old pipes.

Pros and Cons:

  • Good for grease, protein and hair buildup.
  • Safe and Environment friendly
  • A combination of dyes, parabens, phosphates or phthalates.
  • Wasn’t effective for some users.

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Buying Guide

What to Look for while buying Enzyme Drain Cleaner?

Man looking for factors when buying an enzyme drain cleaner.
What to look for when buying an Enzyme Drain Cleaner?


The first factor to look for is whether the product will be effective in its dissolving process or not. Effectiveness can be judged by the formula of the product and reviews by real users. That’s a very difficult task. You can’t spend hours researching. That’s where our article will be of great help for you. We have already done the hard part part for you and have presented the 10 best enzyme drain cleaners to buy in 2020.

Safe and Natural

The second biggest factor is to check whether the product is safe, natural and environment friendly. The product should be safe for animals, plants and marine organisms. Further, the product should be non-pathogenic.

Odor Treatment

An enzyme drain opener should be able to eliminate foul odor.


Pricing is one of the biggest factors while buying any product. You should make it sure that you’re not buying something that is too expensive. Always try to look for alternatives. But remember “do not compromise quality”. I don’t like to brag, but once again “our article will be of great help to you if you want to purchase a budgeted enzyme drain cleaner”.

Reviews by Real Users
There’s a lot of scam on the internet. Companies have started to hire staff whose sole purpose is to buy and review their own product. In the world of scam, be like momi gifts who tries to scan through all the reviews and try to bring only real reviews. Reviews are a key factor to look for when buying any product.

Note: No process is 100% accurate, the same applies to our review “scanning” process. When buying a product recommended by us, please perform your part by acting in due diligence.

What is the best enzyme drain cleaner?

Show the best one
The best

We have reviewed about 10 enzymes drain cleaners. We tried to be neutral as possible. I guess you have got a fair picture as of now. One tough question “which one is the best out of all these 10?”.

My personal choice for the best enzyme drain cleaner is “Green Gobbler ENZYMES for Grease Trap & Sewer”. Let me tell you why.
Although it’s been ranked #5 in our top 10 list but as I said, “This is my personal choice”.

That’s not because all the other 4 above it are useless. They are ranking above it because they have got greater percentage of 5-star reviews.

We have also included another product by Green Gobbler in our list of 10. But this one is different as it has lipase enzymes in it. These enzymes work great while digesting oil molecules. The resulting product is then digested by bacteria.

Why Green Gobbler?

So, Green Gobbler is my personal choice because it has all the features that we should look for when buying an enzyme drain cleaner.

It’s greatly effective in dissolving dead organic wastes naturally. The product is having rapid degradation technology. The product has the capacity to dissolve fats, oils, paper, sludge etc.

The bacteria present in the product is specially developed to degrade fats and oil etc. even as the pH decreases.

How does it work?

It has a de-emulsifying surfactant which helps in the separation of water phase from FOG phase. In its first step, the bacteria separate water from organic wastes. This way, efficacy is increased. Then, Organic waste is liquified and then dissolved.


This enzyme drain opener is budget friendly. If you regularly use it according to instructions, It will help you reduce the frequency of costly septic tanks pumps out.

Safe and Eco-Friendly

The product is safe and eco-friendly. You can use it on all types of pipes. (be it iron or galvanized pipes). The product has a shelf life of two years.

Money Back Guarantee

Green-Gobbler will work, and you’ll find it satisfactory. But if in any case, it didn’t work, they are offering money back guarantee as well (30-days).

Why use enzyme drain cleaner?

Most of the people still like to use the traditional chemicals. This guide will help you avoid such chemicals. Followings are the main reasons:
• Chemicals are often caustic
• They aren’t effective in dissolving all types of clogs
• Chemicals are often unsafe and aren’t environment friendly.
• Such Chemicals are often known to create their own unpleasant scent.

Say no to bleach and use enzyme drain cleaner
No more bleach!

What is the best drain cleaner?

We have analyzed 10 best enzyme drain cleaners. Out of all those, the best drain cleaner is the one by Green Gobbler. Read the article for a detailed analysis on why we selected it as the best. We try to update our reviews from time to time keeping in mind the “valuable suggestions” given by our readers. So, we might change our #1 Choice from time to time.


Do drain cleaning enzymes work?

Yes, most of them do. But be careful, there’re a lot of drain cleaning enzymes that have got reviews but don’t work. So, check our article for an independent review.

Are enzymes safe for drains?

Yes, most of them. In our buying guide, we have included this as a key factor to look for when buying one. All the 10 product included in our list are safe for drains. They are better than chemical cleaners and best for shower drain and floor drain etc.

What is the best drain cleaner for septic systems?

RID-X Septic Tank Treatment Enzymes is the best drain cleaner for septic systems. It has got a great number of 5-star reviews. Read detailed reviews in the article.

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